Sore throat is a frequent companion of colds. A rare respiratory infection does without the appearance of such discomfort. Pain, perspiration, dry cough indicate damage to the upper respiratory tract. Usually this condition is accompanied by fever, runny nose and headache.

In the treatment of diseases of the upper respiratory tract, antiseptics are actively used — sprays, lozenges, lozenges. Among the representatives of this group, it is worth highlighting two funds — Lizobakt and Laripront. The drugs are similar in composition and form of release, and are prescribed in similar clinical situations. How and when antiseptics are used — read the article.

It is important to know: only a doctor should prescribe local antiseptic preparations. The therapist will assess the condition of the upper respiratory tract, make a diagnosis and select a treatment based on the identified symptoms. With the rapid course of the disease, one pill for the throat is not enough, and complex therapy is needed.

What’s inside: compare the composition of drugs

Lizobakt and Laripront belong to the same pharmacological group. These are topical antiseptics — they work only where they are used. They do not penetrate the systemic circulation and do not have a general effect on the body. They are used in ENT practice and dentistry in children and adults. Each drug is described in detail in the table.

How do throat antiseptics work?

Laripront and Lizobakt are combined antiseptics for topical use. The action of drugs is due to their constituent components.

Lizobakt

The composition of the drug includes two components. Lysozyme is an enzyme of protein origin. It directly affects the pathogenic and opportunistic flora: bacteria, fungi, viruses. The enzyme acts on murein and other peptidoglycans that make up the cell wall. Lysozyme is most effective against gram-positive bacteria — it is in their structure that there is a lot of peptidoglycan. The drug also works against viruses — it forms complexes with them and prevents their penetration into the cell.

Other effects:

1. participates in the regulation of immunity — activates non-specific mechanisms to protect the body;

2. has an anti-inflammatory effect — inhibits the development of edema, hyperemia, pain;

3. has a hemostatic effect — accelerates the healing of ulcers on the mucous membrane;

4. is a mucolytic — facilitates sputum production in respiratory tract infections.

Pyridoxine is a form of vitamin B6. It is involved in protein metabolism and protects the cells of the oral mucosa from the effects of negative factors. It does not directly affect the pathogenic flora, but only enhances the action of lysozyme.

The pharmacodynamics of the drug is not indicated in the instructions for use. Since lysozyme and pyridoxine act exclusively locally and do not enter the bloodstream, systemic reactions are not expected.

Laripront

The combined preparation consists of two components. The action of lysozyme was mentioned above. The antiseptic effect of lysozyme is complemented by dequalinium chloride. This substance is active against gram-positive and gram-negative bacteria and fungi. Dequalinium chloride not only has a detrimental effect on the pathogenic flora, but also enhances the action of lysozyme — it facilitates the penetration of the enzyme into the deep layers of the mucous membrane.

Laripront acts only locally. The components of the drug do not penetrate into the bloodstream and do not have a systemic effect.

Evaluation of the effectiveness of drugs

The main active substance of Lyzobact and Laripont — lysozyme — has been studied by researchers since the beginning of the last century. Back in 1922, A. Fleming found out that this enzyme destroys bacteria in the discharge from the nose of a cold patient. Later, scientists discovered that lysozyme was most active against Gram-positive bacteria.

Despite the interest of scientists in lysozyme, we could not find many articles on this problem in the PubMed database. Many materials describe the work of the enzyme only in vitro and do not show how lysozyme works in a specific clinical situation. But there are also articles that deserve attention:

1. One review showed that lysozyme protected and repaired gums from gingivitis and periodontitis. However, the study cannot be called large-scale and randomized in order to seriously focus on it.

2. In another article, the authors analyzed the effect of lysozyme in aphthous stomatitis. Clinical trials have shown that the drug effectively copes with the disease and improves the patient’s condition in three months of treatment.

We have not been able to find conclusive evidence for upper respiratory infection. There is no reliable information on this problem in foreign literature. In Russian-language sources, there is data on the effectiveness of the use of local antiseptics for throat diseases (including in children).

The second component of the preparation Lizobakt — pyridoxine — was added to increase the protective properties of the mucous membrane. Clinical studies show that a lack of vitamin B6 leads to the development of chronic stomatitis. However, there are no double-blind placebo-controlled trials on this issue, so it is impossible to unambiguously talk about the benefits of pyridoxine as part of the drug.

With regard to dequalinium chloride, which is part of the drug Laripront, there is even less information. In the medical literature, it is positioned as an antiseptic for topical use in gynecology. We could not find reliable information on the effect of dequalinium chloride on the microflora of the oral cavity.

Application scheme

Lizobakt is used mainly in dental practice. The drug is prescribed in such situations:

1. gingivitis — inflammation of the gums;

2. stomatitis — damage to the oral mucosa;

3. aphthous ulcers in the oral cavity;

4. complex therapy of herpetic infection with lesions of the oral cavity;

5. erosion of the oral mucosa.

In therapeutic practice, the use of the drug for the treatment of diseases of the upper respiratory tract is allowed. Lizobakt is prescribed only for catarrhal symptoms — redness of the throat, the appearance of pain, perspiration, dry cough. With purulent damage to the respiratory tract and oral cavity, other drugs are prescribed.

Laripront is mainly used in the treatment of respiratory diseases:

1. pharyngitis;

2. laryngitis;

3. angina.

It is allowed to prescribe a drug for the prevention of acute respiratory viral infections when in contact with a sick person and during an epidemic.

In dentistry, Laripront is used to treat diseases of the oral cavity (gingivitis, periodontitis, stomatitis). The drug is also used in the postoperative period — it accelerates the healing of tissues and prevents the development of infectious complications.

The scheme for prescribing antiseptics is similar. The tablet should be kept in the mouth until completely resorbed. The drug should be absorbed slowly, trying to keep it on the mucous membrane as long as possible. After complete dissolution of the tablet, you can not eat or drink for half an hour.

The dosage of the drug is determined by the doctor, taking into account the age of the patient. The course of therapy lasts 5-7 days. The condition improves on the second day from the start of therapy. If after 3 days there is no effect, you need to consult a doctor and change the drug.

Precautionary measures

Laripront and Lyzobakt are well tolerated. In rare cases, allergic reactions occur — a skin rash like urticaria.

Laripront and Lyzobakt are prescribed during pregnancy and lactation. Antiseptics act locally, do not penetrate into the bloodstream and breast milk, do not pass the hematoplacental barrier and do not affect the development of the child.

Laripront has only one contraindication — the identified intolerance to the components of the drug. Lysobact is not used for allergies to chicken protein and in children under 3 years of age.

It’s important to know:

1. Lizobakt enhances the effect of antibiotics with simultaneous use.

2. Simultaneous administration of Lysobact and certain drugs (oral contraceptives, estrogens, immunosuppressants) increases the need for pyridoxine.

conclusions

Briefly about the main:

1. Lizobakt and Laripront are non-specific antiseptics. They are active against many viruses, fungi and bacteria.

2. Laripront is prescribed mainly in the treatment of diseases of the upper respiratory tract — pharyngitis, laryngitis, tonsillitis.

3. Lysobact is more often used in dental practice for the treatment of diseases of the oral cavity.

4. Lizobakt and Laripront act only locally, do not penetrate into the bloodstream. have virtually no side effects. The drugs are well tolerated, used in childhood, during pregnancy and lactation.

The therapeutic efficacy of both drugs is confirmed by clinical trials.